Can we reverse the cruelty of ALS?
A WashU physician-scientist has found a way to stop ALS, and in some patients, reverse it.
ALS has long followed a predictable, devastating script. Independence, speech, and finally breath, slipping away while patients stay fully aware of everything they’re losing. At WashU, Dr. Timothy Miller spent two decades trying to write a different ending. Now he has one: a gene-targeted therapy that shuts off the toxic protein driving the disease before it can destroy nerve cells for good.

A patient once took off her name tag after a talk, put it on my chest, and said, ‘Remember me.’ I still do. It reminds me we have to move faster.
Dr. Timothy Miller
The therapy reaches patients with a genetic form of ALS. Tre was one of them — diagnosed, and told to prepare for the worst. The results were unimaginable.

I should be dead — but I’m still here. I’m thriving.
Tre
I’m living proof of the research.
A diagnosis that no longer means defeat.